Please give me the answer to the A-level Biology Question How does Acetylcholine act on a neuronal synapse, and how is it re-uptaken?

Ca2+ voltage-gated channels are activated because of an action potential being able to reach the synapse Ca2+ voltage-gated channels are activated because of an action potential being able to reach the synapse
- Acetylcholine is found inside the cleft of pre-synaptic synaptic neurons
They are stored in vesicles
- the calcium-induced influx leads the vesicles of the brain to move and to join with the pre-synaptic membrane.
It is when they release the contents (Ach) to the synaptic cell via diffusion via a channel
Ach binds with neuroreceptors located in the post synaptic junction, which causes the channels to expand and depolarisation to take place within the postsynaptic cleft
- The excess Ach inside the synaptic gap is degraded by Acetylcholinesterase and subsequently result in Acetate and Choline
Choline is transported to the axon terminal where it is used to generate an increase in Ach inside the presynaptic neurons.


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Professor Daniel Keaton
Professor Daniel Keaton

Professor Daniel Keaton spent a decade as an A-level subject lead in Maths and Physics before transitioning into higher education as a lecturer in Pedagogy and Assessment, building twelve years of expertise in A-level teaching and exam methodology, academic mentoring for both high-achieving and struggling students, tutor training and first-session design, online tutoring practice and digital learning psychology, as well as guiding families through informed tutoring decisions and supporting tutors in career development, from earning potential to business setup and market positioning.

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